Stock Market Update

23-Dec-25 11:05 ET
Major averages move higher
Dow +69.34 at 48431.81, Nasdaq +60.52 at 23489.38, S&P +15.81 at 6894.29

[BRIEFING.COM] The S&P 500 (+0.2%), Nasdaq Composite (-0.3%), and DJIA (+0.2%) now trade higher across the board. 

Novo Nordisk A/S (NVO 52.16, +4.06, +8.44%) is trading sharply higher after the FDA approved the Wegovy pill for weight loss, making it the first oral GLP-1 receptor agonist approved for chronic weight management. The Wegovy pill delivered weight loss comparable to injectable Wegovy 2.4 mg in the OASIS-4 trial, while reaffirming the well-known safety and tolerability profile of semaglutide.

The FDA approval of the Wegovy pill is a meaningful positive catalyst for Novo Nordisk, as it expands the GLP-1 franchise into a far more patient-friendly format that could significantly broaden adoption. Oral delivery should improve compliance and expand access, particularly among needle-averse patients, while also offering potential cost advantages over injectables. That said, competition is quickly heating up, with Eli Lilly (LLY 1075.04, -1.44, -0.13%) and Pfizer (PFE 25.14, -0.07, -0.27%) both emerging as formidable threats in the obesity market. While today's news helps stabilize sentiment after a challenging period for NVO, long-term upside will depend on execution, pricing power at higher doses, and the company's ability to defend share as rival oral GLP-1s reach the market.

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